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Parthenolide

Parthenolide

Item no.	TMO-T2140-25mg
Manufacturer	TargetMol
CASRN	20554-84-1
Amount	25 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 1 mL 200 mg 25 mg 50 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Signaling Reagents & Chemicals Molecules By Organ Lung Cancer
Type	Molecules
Specific against	other
Citations	1. Lin M, et al. Parthenolide suppresses non-small cell lung cancer GLC-82 cells growth via B-Raf/MAPK/Erk pathway. Oncotarget. 2017 Apr 4;8(14):23436-23447.
Smiles	C\C1=C/CC[C@@]2(C)O[C@H]2[C@H]2OC(=O)C(=C)[C@@H]2CC1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	(-)-Parthenolide
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Apoptosis\|\|\|NF-κB\|\|\|Mitophagy\|\|\|Autophagy\|\|\|HDAC
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	248.32
Description	Parthenolide ((-)-Parthenolide) is a natural sesquiterpene lactone that is an NF-κB inhibitor and also specifically inhibits HDAC1 protein, but is inactive against other class I/II HDACs. Parthenolide has anti-inflammatory, anti-tumor, and anti-viral activities.
Pathways	NF-κB\|\|\|Chromatin/Epigenetic\|\|\|Apoptosis\|\|\|Autophagy\|\|\|DNA Damage/DNA Repair
Bioactivity	(-)-Parthenolide is a sesquiterpene lactone which occurs naturally in the plant feverfew(Tanacetum parthenium) and also promotes the ubiquitination of MDM2 and activates p53 cellular functions.
Receptor	NF-kappaB

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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