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Fulvestrant

Fulvestrant

Item no.	TMO-T2146-200mg
Manufacturer	TargetMol
CASRN	129453-61-8
Amount	200 mg
Quantity options	100 mg 10 mM x 1 mL (in DMSO) 10 mg 1 mg 200 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	0,9989
Citations	1. Wakeling AE, et al. Y Res, 1991, 51(15), 3867-3873.
Smiles	[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])c3ccc(O)cc3C[C@@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)[C@@]21[H]
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	ZM 182780, ZD 9238, ICI 182780
Shipping condition	Cool pack
Available
Manufacturer - Targets	Estrogen Receptor/ERR\|\|\|Estrogen/progestogen Receptor\|\|\|Apoptosis\|\|\|Autophagy
Shipping Temperature	cool pack
Storage Conditions	-20°
Molecular Weight	606, 77
Description	Fulvestrant (ZM 182780) is an estrogen receptor (ER) antagonist (IC50=9.4 nM) and an agonist of GPR30. Fulvestrant has antitumor activity, inhibiting cell proliferation and inducing apoptosis and autophagy.
Bioactivity	Fulvestrant is a steroidal antiestrogen that is used in the treatment of hormone-receptor positive metastatic breast cancer. Fulvestrant therapy can be associated with serum enzyme elevations, but has yet to be linked to instances of clinically apparent acute liver injury in the published literature.
Pathways	Apoptosis\|\|\|Endocrinology/Hormones\|\|\|Autophagy
Receptor	ER

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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