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(S)-Afatinib

(S)-Afatinib

Item no.	TMO-T2303-2mg
Manufacturer	TargetMol
CASRN	439081-18-2
Amount	2 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 g 1 mL 200 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	1
Citations	1. Prim N, et al. Rev Pneumol Clin. 2014 Oct;70(5):279-85.
Smiles	CN(C)CC=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	BIBW2992
Shipping Condition	Cool pack
Available
Manufacturer - Targets	HER\|\|\|EGFR
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	485.94
Description	(S)-Afatinib (BIBW2992) is an irreversible EGFR family inhibitor with IC50s of 0.5/0.4/10/14/1 nM for EGFRwt, EGFR (L858R), EGFR (L858R/T790M), HER2, and HER4, respectively.
Pathways	Angiogenesis\|\|\|Tyrosine Kinase/Adaptors\|\|\|JAK/STAT signaling
Bioactivity	Afatinib is a tyrosine kinase receptor inhibitor that is used in the therapy of selected forms of metastatic non-small cell lung cancer.
Receptor	EGFR (L858R); EGFR (L858R/T790M); EGFR (wt); HER2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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