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Vemurafenib

Vemurafenib

Item no.	TMO-T2382-1000mg
Manufacturer	TargetMol
CASRN	918504-65-1
Amount	1000 mg
Quantity options	1000 mg 100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 200 mg 25 mg 500 mg 50 mg
Category	Oncology Reagents & Chemicals Molecules By Organ Colorectal Cancer
Type	Molecules
Specific against	other
Citations	1. Bollag G, et al. Nature, 2010, 467(7315), 596-599.
Smiles	C(=O)(C=1C=2C(NC1)=NC=C(C2)C3=CC=C(Cl)C=C3)C4=C(F)C(NS(CCC)(=O)=O)=CC=C4F
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	RO5185426,RG7204,PLX4032
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Src\|\|\|Raf\|\|\|MAPK\|\|\|Autophagy\|\|\|ACK1
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	489.92
Description	Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently. Vemurafenib exhibits antitumor activity and is used for the treatment of BRAF V600E mutation-positive melanoma.
Pathways	MAPK\|\|\|Autophagy\|\|\|Tyrosine Kinase/Adaptors\|\|\|Angiogenesis
Bioactivity	Vemurafenib (PLX4032, RG7204) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay
Receptor	ACK1; BLK; BRK; MAP4K5 (KHS1); NEK11; MNK2; B-Raf; B-Raf (V600E); C-Raf; SRMS; Lyn B; FGR; Lck; Src; Yes1; CSK; FRK (PTK5); WNK3

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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