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MK-8745

MK-8745

Item no.	TMO-T2471-100mg
Manufacturer	TargetMol
CASRN	885325-71-3
Amount	100 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 200 mg 25 mg 50 mg 5 mg
Category	Oncology Reagents & Chemicals Molecules By Organ Lymphatic System Cancer
Type	Molecules
Specific against	other
Citations	1. Chowdhury A, et al. Leuk Lymphoma. 2012, 53(3), 462-471.
Smiles	Fc1c(Cl)cccc1C(=O)N1CCN(Cc2cccc(Nc3nccs3)n2)CC1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Aurora Kinase inhibitor
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Aurora Kinase\|\|\|Apoptosis
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	431.91
Description	MK-8745 is a potent and selective Aurora A inhibitor.
Pathways	Chromatin/Epigenetic\|\|\|Apoptosis\|\|\|Cell Cycle/Checkpoint
Bioactivity	MK-8745 is a potent and selective Aurora A inhibitor with IC50 of 0.6 nM, more than 450-fold selectivity for Aurora A over Aurora B.
Receptor	Aurora A; Aurora B

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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