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PLX-4720

PLX-4720

Item no.	TMO-T2473-200mg
Manufacturer	TargetMol
CASRN	918505-84-7
Amount	200 mg
Quantity options	100 mg 10 mM x 1 mL (in DMSO) 10 mg 1 mL 200 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Tsai J, et al. Proc Natl Acad Sci U S A, 2008, 105(8), 3041-3046.
Smiles	CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	PLX4720
Shipping condition	Cool pack
Available
Manufacturer - Targets	Raf
Shipping Temperature	cool pack
Storage Conditions	-20°
Molecular Weight	413, 83
Description	PLX-4720, a potent and selective inhibitor of B-Raf (V600E) with an IC50 of 13 nM, is equally effective against c-Raf-1 (Y340D and Y341D mutations).
Bioactivity	PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf.
Pathways	MAPK
Receptor	BRK; B-Raf; B-Raf (V600E); C-Raf-1 (Y340D/Y341D); FRK

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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