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AT13148

AT13148

Item no.	TMO-T2482-100mg
Manufacturer	TargetMol
CASRN	1056901-62-2
Amount	100 mg
Quantity options	100 mg 10 mM x 1 mL (in DMSO) 10 mg 1 mg 1 mL 25 mg 2 mg 50 mg 5 mg
Category	Neuroscience Metabolism Diabetes Aging & Neurological Disorders Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Yap TA, et al. Clin Y Res. 2012, 18(14), 3912-3923.
Smiles	NC[C@@](O)(c1ccc(Cl)cc1)c1ccc(cc1)-c1cn[nH]c1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Akt inhibitor; PKA inhibitor; ROCK inhibitor; S6 Kinase inhibitor; SGK inhibitor
Shipping condition	Cool pack
Available
Manufacturer - Targets	SGK\|\|\|ROCK\|\|\|S6 Kinase\|\|\|PKA\|\|\|Akt
Shipping Temperature	cool pack
Storage Conditions	-20°
Molecular Weight	313, 78
Description	AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
Bioactivity	AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively. Phase 1.
Pathways	Cell Cycle/Checkpoint\|\|\|PI3K/Akt/mTOR signaling\|\|\|Metabolism\|\|\|Stem Cells\|\|\|MAPK\|\|\|Cytoskeletal Signaling\|\|\|Tyrosine Kinase/Adaptors
Receptor	Akt1; Akt2; Akt3; PKA; ROCK1; ROCK2; p70 S6K; RSK1; SGK3

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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