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PD 151746

PD 151746

Item no.	TMO-T2493-1ml
Manufacturer	TargetMol
CASRN	179461-52-0
Amount	1 mL
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Smiles	OC(=O)C(S)=Cc1c[nH]c2ccc(F)cc12
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	Proteasome,Proteasome,Cysteine Protease
Similar products	179461-52-0
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Proteasome\|\|\|Cysteine Protease
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	237.25
Description	PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0.03 μM (Ki for μ-calpain) and 5.33 ± 0.77 μM (Ki for m-calpain) [1]. In vitro, PD151746 targets calpain and reduces oxLDL-induced cytotoxicity [2].
Pathways	Proteases/Proteasome\|\|\|Ubiquitination

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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