Comparison

Canertinib dihydrochloride European Partner

Item no. TMO-T2501-200mg
Manufacturer TargetMol
CASRN 289499-45-2
Amount 200 mg
Quantity options 100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 200 mg 25 mg 50 mg 5 mg
Category
Type Molecules
Specific against other
Citations 1. Smaill JB et al. J Med Chem. 2000; 43(7): 1380-1397.
Smiles Cl.Cl.Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl
ECLASS 10.1 32169090
ECLASS 11.0 32169090
UNSPSC 12000000
Alias CI-1033 dihydrochloride,PD-183805 dihydrochloride
Shipping Condition Cool pack
Available
Manufacturer - Targets
EGFR
Shipping Temperature
Cool pack
Storage Conditions
-20
Molecular Weight
558.86
Description
Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities.
Pathways
JAK/STAT signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors
Bioactivity
Canertinib Dihydrochloride is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities. Canertinib binds to the intracellular domains of epidermal growth factor receptor tyrosine kinases (ErbB family), irreversibly inhibiting their signal transduction functions and resulting in tumor cell apoptosis and suppression of tumor cell proliferation. This agent also acts as a radiosensitizing agent and displays synergistic activity with other chemotherapeutic agents.
Receptor
EGFR; HER2/ErbB2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 200 mg
Available: In stock
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