G-749

Item no.	TMO-T2620-2mg
Manufacturer	TargetMol
CASRN	1457983-28-6
Amount	2 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 200 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Oncology Reagents & Chemicals Molecules By Organ Colorectal Cancer
Type	Molecules
Specific against	other
Citations	1. Lee HK, et al. Blood. 2014, 123(14), 2209-2219.
Smiles	CN1CCC(CC1)Nc1nc(Nc2ccc(Oc3ccccc3)cc2)c2c(n1)c(Br)c[nH]c2=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Denfivontinib,G749
Shipping Condition	Cool pack
Available
Manufacturer - Targets	TAM Receptor\|\|\|Aurora Kinase\|\|\|c-RET\|\|\|FLT\|\|\|Apoptosis
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	521.41
Description	G-749, a new-type FLT3 inhibitor, exhibits effective and sustained inhibition of the FLT3 wild type and mutants.
Pathways	Chromatin/Epigenetic\|\|\|Tyrosine Kinase/Adaptors\|\|\|Cell Cycle/Checkpoint\|\|\|Apoptosis\|\|\|Angiogenesis
Bioactivity	G-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y), and Mer, respectively, showing lower potency against other tyrosine kinases.
Receptor	Aurora B; RET; FLT3; FLT3 (D835Y); Mer

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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