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Nolatrexed dihydrochloride

Nolatrexed dihydrochloride

Item no.	TMO-T2627-10mM
Manufacturer	TargetMol
CASRN	152946-68-4
Amount	10 mM x 1 mL (in DMSO)
Quantity options	10 mM x 1 mL (in DMSO) 10 mg 1 mg 25 mg 2 mg 50 mg 5 mg
Category	Metabolism Cholesterol & Lipid Metabolism Enzymes Other Fatty Acid Enzymes Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	0,98
Smiles	Cl.Cl.Cc1ccc2[nH]c(N)nc(=O)c2c1Sc1ccncc1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Thymitaq, AG 337
Shipping Condition	Cool pack
Available
Manufacturer - Targets	DNA/RNA Synthesis
Shipping Temperature	cool pack
Storage Conditions	-20°
Molecular Weight	357, 26
Description	Nolatrexed dihydrochloride (Thymitaq) is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.
Formulate	C14H14Cl2N4OS
Pathways	Cell Cycle/Checkpoint\|\|\|DNA Damage/DNA Repair

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mM x 1 mL (in DMSO)

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