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Olaparib

Olaparib

Item no.	TMO-T3015-1000mg
Manufacturer	TargetMol
CASRN	763113-22-0
Amount	1000 mg
Quantity options	1000 mg 100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 g 200 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Menear KA, et al. J Med Chem, 2008, 51(20), 6581-6591.
Smiles	C(C=1C=2C(C(=O)NN1)=CC=CC2)C3=CC(C(=O)N4CCN(C(=O)C5CC5)CC4)=C(F)C=C3
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	AZD2281,KU0059436
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Mitophagy\|\|\|Autophagy\|\|\|PARP
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	434.46
Description	Olaparib (KU0059436) is a small molecule inhibitor of PARP1/PARP2 (IC50=5/1 nM), with weak inhibitory activity against PARP tankyrase-1 (IC50=1.5 μM), and is selective and orally active. Olaparib exhibits autophagy and mitochondrial autophagy activation activity.
Pathways	DNA Damage/DNA Repair\|\|\|Chromatin/Epigenetic\|\|\|Autophagy
Bioactivity	Olaparib (AZD2281, KU0059436) is a potent PARP inhibitor with IC50 of 5 and 1 nM for PARP-1and PARP-2, respectively.
Receptor	PARP1; PARP2; PARP2

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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