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A 83-01

A 83-01

Item no.	TMO-T3031-100mg
Manufacturer	TargetMol
CASRN	909910-43-6
Amount	100 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Oncology By Cell Type Glioma Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	0,99
Citations	1. Tojo M, et al. Y Sci. 2005 Nov;96(11):791-800.
Smiles	Cc1cccc(n1)-c1nn(cc1-c1ccnc2ccccc12)C(=S)Nc1ccccc1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	ALK5 Inhibitor IV,A8301
Shipping Condition	Cool pack
Available
Manufacturer - Targets	TGF-beta/Smad\|\|\|ALK
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	421.52
Description	A 83-01 (ALK5 Inhibitor IV) is an inhibitor of the TGF-β type I receptors ALK5, ALK4, and ALK7 (IC50=12/45/7.5 nM). A 83-01 promotes the reprogramming of mouse fibroblasts into iPSCs. A 83-01 can be used in organoid cultures.
Pathways	Stem Cells\|\|\|Tyrosine Kinase/Adaptors\|\|\|Angiogenesis
Bioactivity	A 83-01 is a selective inhibitor of TGF-beta type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 with IC50 values of 12 nM, 45 nM and 7.5 nM, respectively.
Receptor	ALK4; ALK5; ALK7

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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