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GSK1838705A

GSK1838705A

Item no.	TMO-T3079-100mg
Manufacturer	TargetMol
CASRN	1116235-97-2
Amount	100 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 25 mg 2 mg 50 mg 5 mg
Category	Oncology Neuroscience Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Molecular Targets for Neuroscience Reagents & Chemicals Molecules By Organ Colorectal Cancer
Type	Molecules
Specific against	other
Citations	1. Sabbatini P, et al. Mol Y Ther. 2009, 8(10), 2811-2820.
Smiles	CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)nc2[nH]ccc12
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Targets	JNK\|\|\|ALK\|\|\|S6 Kinase\|\|\|IGF-1R
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	532.57
Description	GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to other protein kinases.
Pathways	MAPK\|\|\|Tyrosine Kinase/Adaptors\|\|\|Angiogenesis\|\|\|PI3K/Akt/mTOR signaling
Bioactivity	GSK1838705A is a potent IGF-1R inhibitor with IC50 of 2.0 nM, modestly potent to IR and ALK with IC50 of 1.6 nM and 0.5 nM, respectively, and little activity to other protein kinases.
Receptor	ALK; IGF-1R; Insulin Receptor; JNK3; RSK1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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