COH29

Item no.	TMO-T3157-25mg
Manufacturer	TargetMol
CASRN	1190932-38-7
Amount	25 mg
Quantity options	100 mg 10 mM x 1 mL (in DMSO) 10 mg 1 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Zhou B, et al. Y Res. 2013 Nov 1;73(21):6484-93.
Smiles	Oc1ccc(cc1O)C(=O)Nc1nc(c(s1)-c1ccccc1)-c1ccc(O)c(O)c1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	RNR Inhibitor COH29
Shipping Condition	Cool pack
Available
Manufacturer - Targets	DNA/RNA Synthesis
Shipping Temperature	cool pack
Storage Conditions	-20°
Molecular Weight	420, 44
Target names or alias	RNR Inhibitor COH29
Description	COH29 (RNR Inhibitor COH29) is an orally available, aromatically substituted thiazole and human ribonucleotide reductase (RNR) inhibitor with potential antineoplastic activity. COH29 binds to the ligand-binding pocket of the RNR M2 subunit (hRRM2) near the C-terminal tail, decreasing the pool of deoxyribonucleotide triphosphates needed for DNA synthesis, leading to cell cycle arrest and growth inhibition. It may also inhibit the nuclear enzyme poly (ADP-ribose) polymerase (PARP) 1, preventing DNA repair, causing accumulation of DNA breaks, and inducing apoptosis.
Pathways	DNA Damage/DNA Repair\|\|\|Cell Cycle/Checkpoint

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