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AM-2394

AM-2394

Item no.	TMO-T3312-10mg
Manufacturer	TargetMol
CASRN	1442684-77-6
Amount	10 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 1 mg 200 mg 25 mg 2 mg 50 mg 5 mg
Category	Metabolism Diabetes Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Dransfield PJ, et al. ACS Med Chem Lett. 2016 May 23;7(7):714-8.
Smiles	CNC(=O)Nc1cc(Oc2cncc(C)c2)c(cn1)-c1ccc(OCC(C)(C)O)nc1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	AM2394
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Glucokinase
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	423.46
Description	AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394(AM2394) increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes.
Pathways	Metabolism

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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