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Homoharringtonine

Homoharringtonine

Item no.	TMO-T3380-200mg
Manufacturer	TargetMol
CASRN	26833-87-4
Amount	200 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 200 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	0,99
Citations	1. Jin J, et al. Lancet Oncol. 2013 Jun;14(7):599-608.
Smiles	COC(=O)CC(O)(CCCC(C)(C)O)C(=O)OC1C2c3cc4OCOc4cc3CCN3CCCC23C=C1OC
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Omacetaxine mepesuccinate,Myelostat,Ceflatonin,HHT
Shipping Condition	Cool pack
Available
Manufacturer - Targets	STAT
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	545.62
Description	Homoharringtonine (HHT) is a natural alkaloid that inhibits the translation of proteins and is cytotoxic. Homoharringtonine acts on the ribosomes of tumor cells to inhibit the elongation step of protein translation, thereby inhibiting protein synthesis, and has antitumor activity.
Pathways	JAK/STAT signaling\|\|\|Stem Cells
Bioactivity	Homoharringtonine is an alkaloid inhibitor of protein synthesis with activity in myeloid malignancies. It might have clinical activity in some patients with myelodysplastic syndrome. Homoharringtonine enhances the paracellular permeability of Caco-2 cell monolayers by modulating the protein expression and localization of claudin isoforms. Homoharringtonine has anti-Y and antileukemic activities may have the potential ability to treat acute, chronic myeloid leukemia and Gefitinib-resistant NSCLC.
Receptor	STAT3

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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