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Cucurbitacin B

Cucurbitacin B

Item no.	TMO-T3404-100mg
Manufacturer	TargetMol
CASRN	6199-67-3
Amount	100 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 200 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	0,993
Citations	1. Shang Y, et al. Eur Rev Med Pharmacol Sci. 2014;18(21):3297-303.
Smiles	CC(=O)OC(C)(C)C=CC(=O)C(C)(O)C1C(O)CC2(C)C3CC=C4C(CC(O)C(=O)C4(C)C)C3(C)C(=O)CC12C
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Amarine,Cuc B,DATISCACIN
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Autophagy\|\|\|STAT\|\|\|Apoptosis\|\|\|Integrin\|\|\|Endogenous Metabolite\|\|\|PTEN\|\|\|HIF
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	558.7
Description	Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells.
Pathways	PI3K/Akt/mTOR signaling\|\|\|Angiogenesis\|\|\|JAK/STAT signaling\|\|\|Chromatin/Epigenetic\|\|\|Metabolism\|\|\|Cytoskeletal Signaling\|\|\|Apoptosis\|\|\|Autophagy\|\|\|Stem Cells

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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