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Demethylzeylasteral

Demethylzeylasteral

Item no.	TMO-T3418-200mg
Manufacturer	TargetMol
CASRN	107316-88-1
Amount	200 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 200 mg 20 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	0,9894
Citations	1. Liu SL et al. Eur J Drug Metab Pharmacokinet. 2014 Jun;39(2):99-102.
Smiles	[H][C@@]12C[C@@](C)(CC[C@]1(C)CC[C@]1(C)C3=CC(=O)c4c(C=O)c(O)c(O)cc4[C@]3(C)CC[C@@]21C)C(O)=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Demethylzeylasteral (T-96)
Shipping Condition	Cool pack
Available
Manufacturer - Targets	UGT\|\|\|Apoptosis
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	480.59
Description	Demethylzeylasteral (T-96), isolated from Tripterygium wilfordii, has anti-inflammatory, immunosuppressive and anti-tumor activities. It inhibits the invasion of triple-negative breast cancer by blocking the TGF-β signaling pathway, and it can significantly reduce atherosclerosis.
Pathways	Apoptosis\|\|\|Metabolism
Bioactivity	Demethylzeylasteral has strong immunosuppressive activity, can be used in the fields of organ transplantation and autoimmune disorders. The risk of elevated serum concentrations of estradiol due to the inhibition of estradiol glucuronidation by Demethylzeylasteral. Demethylzeylasteral increases both activation and inactivation time constants of Ca(2+) currents, can inhibit significantly the sperm acrosome reaction initiated by progesterone.
Receptor	UGT1A6; UGT2B7

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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