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RO 46-8443

RO 46-8443

Item no.	TMO-T3474-2mg
Manufacturer	TargetMol
CASRN	175556-12-4
Amount	2 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 200 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Oncology Reagents & Chemicals Molecules By Organ Lung Cancer
Type	Molecules
Specific against	other
Citations	1.Guimaraes CL, Trentin PG, Rae GA. Endothelin ET(B) receptor-mediated mechanisms involved in oleic acid-induced acute lung injury in mice. Clin Sci (Lond). 2002 Aug;103 Suppl 48:340S-344S.
Smiles	COc1ccc(cc1)-c1nc(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)c(Oc2ccccc2OC)c(OC[C@H](O)CO)n1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Endothelin Receptor antagonist
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Endothelin Receptor
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	609.69
Description	RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition.
Pathways	GPCR/G Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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