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Halofuginone hydrobromide

Halofuginone hydrobromide

Item no.	TMO-T3524-2mg
Manufacturer	TargetMol
CASRN	64924-67-0
Amount	2 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	0,99
Citations	1. Zhou H. et al. ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase. Nature. 2013 Feb 7;494(7435):121-4.
Smiles	Br.O[C@H]1CCCN[C@@H]1CC(=O)Cn1cnc2cc(Br)c(Cl)cc2c1=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Tempostatin,RU-19110 (hydrobromide),Stenorol
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Calcium Channel\|\|\|Parasite\|\|\|TGF-beta/Smad\|\|\|Sodium Channel\|\|\|DNA/RNA Synthesis
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	495.59
Description	Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.
Pathways	DNA Damage/DNA Repair\|\|\|Cell Cycle/Checkpoint\|\|\|Membrane transporter/Ion channel\|\|\|Microbiology/Virology\|\|\|Metabolism\|\|\|Stem Cells

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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