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Senicapoc

Senicapoc

Item no.	TMO-T3528-10mM
Manufacturer	TargetMol
CASRN	289656-45-7
Amount	10 mM x 1 mL (in DMSO)
Quantity options	100 mg 10 mM x 1 mL (in DMSO) 10 mg 1 mL 200 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Ataga KI, et al. Senicapoc (ICA-17043): a potential therapy for the prevention and treatment of hemolysis-associated complications in sickle cell anemia. Expert Opin Investig Drugs. 2009 Feb;18(2):231-9.
Smiles	NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	ICA-17043
Shipping condition	Cool pack
Available
Manufacturer - Targets	Potassium Channel
Shipping Temperature	cool pack
Storage Conditions	-20°
Molecular Weight	323, 34
Description	Senicapoc (ICA-17043) is a potent inhibitor of the Gardos channel that ameliorates RBC dehydration in the SAD mouse. It blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 ± 2 nM (CLT IC50 = 100 ± 12 nM) and inhibits RBC dehydration with an IC50 of 30 ± 20 nM. Senicapoc is used in the treatment of Sickle Cell Disease and Sickle Cell Anemia.
Bioactivity	Senicapoc is a potent inhibitor of the Gardos channel and ameliorates RBC dehydration in the SAD mouse. Senicapoc blocked Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 +/- 2 nM (CLT IC50 = 100 +/- 12 nM) and inhibited RBC dehydration with an IC50 of 30 +/- 20 nM. Senicapoc is in treatment of Sickle Cell Disease and Sickle Cell Anemia
Pathways	Membrane transporter/Ion channel
Receptor	Gardos channel

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Amount: 10 mM x 1 mL (in DMSO)

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