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Avadomide

Avadomide

Item no.	TMO-T3549-10mM
Manufacturer	TargetMol
CASRN	1015474-32-4
Amount	1 mL x 10 mM (in DMSO)
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 200 mg 25 mg 2 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Development Reagents & Chemicals Molecules By Organ Heart & Blood Cancer
Type	Molecules
Specific against	other
Citations	1. Patrick R. Hagner, et al. Blood. 2015 Aug 6; 126(6): 779–789.
Smiles	Cc1nc2cccc(N)c2c(=O)n1C1CCC(=O)NC1=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	CC 122
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Apoptosis\|\|\|E1/E2/E3 Enzyme\|\|\|Ligand for E3 Ligase
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	286.29
Description	Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity.
Pathways	Apoptosis\|\|\|Ubiquitination\|\|\|PROTAC
Bioactivity	CC-122 is an orally available pleiotropic pathway modulator with potential antineoplastic activity. CC-122 mimics an interferon response and has antitumor activity in DLBCL CC-122 binds Cereblon (CRBN) and promotes degradation of Aiolos and Ikaros in diffuse large B-cell lymphoma (DLBCL) and T cells in vitro, in vivo, and in patients, resulting in both cell autonomous as well as immunostimulatory effects.
Receptor	Others

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 mL x 10 mM (in DMSO)

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