A-366

Item no.	TMO-T3624-10mg
Manufacturer	TargetMol
CASRN	1527503-11-2
Amount	10 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 200 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Pappano WN, et al. PLoS One. 2015, 10(7):e0131716.
Smiles	COc1cc2c(cc1OCCCN1CCCC1)N=C(N)C21CCC1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	A 366,A366
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Epigenetic Reader Domain\|\|\|Histone Methyltransferase
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	329.44
Description	A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than 1, 000-fold selective for G9a and GLP over the other 21 methyltransferases. It is an inhibitor of the Spindlin1-H3K4me3 interaction with an IC50 of 182.6 nM.It exhibits high affinity for human H3R with a Ki value of 17 nM, and shows subtype selectivity between subgroups of the histaminergic and dopaminergic receptor families.
Pathways	Chromatin/Epigenetic

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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