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Crenigacestat

Crenigacestat

Item no.	TMO-T3633-10mM
Manufacturer	TargetMol
CASRN	1421438-81-4
Amount	10 mM x 1 mL (in DMSO)
Quantity options	100 mg 10 mM x 1 mL (in DMSO) 10 mg 1 mg 1 mL 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Warren JP. Discovery of a Novel Notch Inhibitor. The 8th SCI-RSC Symposium on Proteinase Inhibitor Design April 15-16, 2013, Basel, Switzerland.
Smiles	C[C@H](NC(=O)CCC(F)(F)F)C(=O)N[C@H]1c2ccccc2-c2cccnc2N(CCO)C1=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	LY3039478
Shipping condition	Cool pack
Available
Manufacturer - Targets	Gamma-secretase
Shipping Temperature	cool pack
Storage Conditions	-20°
Molecular Weight	464, 44
Description	Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most tumor cell lines tested. It effectively inhibits mutant Notch receptor activity and, in a xenograft tumor model, inhibits the expression of Notch-regulated genes and N1ICD cleavage in the tumor microenvironment.
Bioactivity	LY3039478 a orally bioavailable, novel small molecule Notch inhibitor with an IC50 of ca.1nM in most of the tumor cell lines tested. LY3039478 potently inhibits mutant Notch receptor activity. In a xenograft tumor model, LY3039478 inhibited N1ICD cleavage and expression of Notch-regulated genes in the tumor microenvironment. LY3039478 is being investigated in Phase I.
Pathways	Stem Cells\|\|\|Neuroscience\|\|\|Proteases/Proteasome
Receptor	Notch-1

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mM x 1 mL (in DMSO)

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