« Back
Home /
(E)-SIS3

(E)-SIS3

Item no.	TMO-T3636-25mg
Manufacturer	TargetMol
CASRN	521984-48-5
Amount	25 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 200 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Neural Signaling Reagents & Chemicals Molecules By Organ Colorectal Cancer Neurodegeneration Markers
Type	Molecules
Specific against	other
Citations	1. Boudreau HE, et al. Br J Y. 2014 May 13;110(10):2569-82.
Smiles	Cl.COc1cc2CCN(Cc2cc1OC)C(=O)\C=C\c1c(-c2ccccc2)n(C)c2ncccc12
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	SIS3 hydrobromide,SIS3 HCl
Shipping Condition	Cool pack
Available
Manufacturer - Targets	TGF-beta/Smad
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	489.99
Description	(E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts and inhibits TGF-β2-induced endothelial cell differentiation in iPSCs.
Pathways	Stem Cells

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

TMO-T3636-25mg-datasheet.pdf

Request safety datasheet

Simple Order Order Subscription

Amount: 25 mg

available

Compare

Add to wishlist

Get an offer

Request delivery time

Ask a technical question