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Pifithrin-β hydrobromide

Pifithrin-β hydrobromide

Item no.	TMO-T3637-25mg
Manufacturer	TargetMol
CASRN	511296-88-1
Amount	25 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 25 mg 2 mg 50 mg 5 mg
Category	Oncology Reagents & Chemicals Molecules By Organ Lung Cancer
Type	Molecules
Specific against	other
Citations	1. Abdelalim EM, et al.Biochem Biophys Res Commun. 2012 Apr 13;420(3):605-10.
Smiles	Br.Cc1ccc(cc1)-c1cn2c3CCCCc3sc2n1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Cyclic Pifithrin-α hydrobromide,Cyclic PFT-α,PFT-β,Pifithrin-β,PFT β (hydrobromide)
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Ferroptosis\|\|\|p53
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	349.29
Description	Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of Y therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 μM).
Pathways	Apoptosis

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25 mg

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