ISO-1

Others

-20

ISO-1 (MIF Antagonist) is an inhibitor of the dopachrome tautomerase activity, blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages.

Macrophage migration inhibitory factor (MIF) is a regulator of inflammation that also has roles in Y and autoimmune diseases. MIF exhibits both tautomerase and oxidoreductase activities, although how these are linked to MIF’s physiological and pathophysiological actions is unclear. MIF antagonist, also known as ISO-1, is an inhibitor of the dopachrome tautomerase activity of MIF in vitro (IC50 = 7 uM) and in cells (IC50 = 25 uM). It blocks the activation of NF-kappaB and TNF-alpha secretion from LPS-treated macrophages and improves the survival of mice following sepsis. MIF antagonist also demonstrates protective effects in airway and gastrointestinal inflammation in mice.