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A-740003

A-740003

Item no.	TMO-T3690-10mM
Manufacturer	TargetMol
CASRN	861393-28-4
Amount	1 mL x 10 mM (in DMSO)
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 200 mg 2 mg 50 mg 5 mg
Category	Oncology Reagents & Chemicals Molecules By Organ Nervous System Cancer
Type	Molecules
Specific against	other
Citations	1. Honore P, et al. J Pharmacol Exp Ther. 2006 Dec;319(3):1376-85.
Smiles	COc1ccc(CC(=O)NC(N\C(Nc2cccc3ncccc23)=N\C#N)C(C)(C)C)cc1OC
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	A 740003
Shipping Condition	Cool pack
Available
Manufacturer - Targets	P2X Receptor
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	474.55
Description	A-740003 (A 740003) is an effective and specific P2X7 receptor antagonist (IC50: 18/40 nM, for rat/human). It can reduce nociception in animal models of persistent neuropathic and inflammatory pain, and also reduce neuroblastoma tumor growth in mice.
Pathways	Neuroscience\|\|\|Membrane transporter/Ion channel
Bioactivity	Potent and selective P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively). Displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 uM. Reduces nociception in animal models of persistent neuropathic and inflammatory pain. Also reduces neuroblastoma tumor growth in mice.
Receptor	P2X7 (Human); rat P2X7 receptor

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 mL x 10 mM (in DMSO)

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