3',6-Disinapoylsucrose

Epigenetic Reader Domain|||Bcl-2 Family

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3', 6-Disinapoylsucrose (Disinapoyl sucrose) shows the neuroprotective effect and antidepressive activity in rats.

3, 6'-Disinapoyl sucrose has neuroprotective effect and antidepressive activity in rats, at least in part, by increasing expression of cyclic AMP response element (CRE)-binding protein (CREB) and its downstream target protein, brain-derived neurotrophic factor (BDNF). Treatment with 3, 6'-Disinapoyl sucrose (0.6, 6, and 60?umol/L) increases cell viability dose dependently, inhibits LDH release, and attenuated apoptosis. The mechanisms by which 3, 6'-Disinapoyl sucrose protect neuron cells from glutamate-induced excitotoxicity include the downregulation of proapoptotic gene Bax and the upregulation of antiapoptotic gene Bcl-2.