Ginsenoside C-K

Cytochromes P450|||Cell Cycle Arrest|||COX|||NO Synthase

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Ginsenoside C-K (Ginsenoside K) is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2.

Ginsenoside compound K (C-K) could be a potentially effective anti-colorectal cancer agent. C-K showed significant anti-proliferative effects in HCT-116 and SW-480 cells at concentrations of 30-50 uM.C-K could be a potential drug for pediatric AML intervention and to improve the outcome of pediatric AML treatment, via significant G1 cell cycle arrest and apoptosis. C-K reduced the expression levels of the inducible NO synthase (iNOS) and COX-2 proteins and inhibited the activation of NF-kB, a nuclear transcription factor. 5. Ginsenoside Rb1 can be transformed to CK by intestinal bacteria, and C-K may be effective against inflammation.