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Polygalasaponin F

Polygalasaponin F

Item no.	TMO-T3826-5mg
Manufacturer	TargetMol
CASRN	882664-74-6
Amount	5 mg
Quantity options	100 mg 10 mg 1 mL 1 mg 200 mg 20 mg 25 mg 2 mg 50 mg 5 mg
Category	Neuroscience Metabolism Diabetes Glucose Homeostasis Molecular Targets for Neuroscience Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Zhou W,et al. Quantification of polygalasaponin F in rat plasma using liquid chromatography-tandem mass spectrometry and its pharmacokinetics application. Biomed Chromatogr. 2015 Sep;29(9):1388-92.
Smiles	C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2OC(=O)[C@]23CCC(C)(C)C[C@H]2C2=CC[C@@H]4[C@@]5(C)C[C@H](O)[C@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)[C@@](C)(CO)[C@@H]5CC[C@@]4(C)[C@]2(C)CC3)[C@H](O)[C@H](O)[C@H]1O[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	NF-kappaB inhibitor
Shipping condition	Cool pack
Available
Manufacturer - Targets	TLR\|\|\|NF-κB\|\|\|Akt\|\|\|PI3K
	PI3K
Shipping Temperature	cool pack
Storage Conditions	-20°
Molecular Weight	1091, 24
Description	Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Polygalasaponin F can significantly inhibit the cytotoxicity of conditioned medium prepared by LPS-stimulated BV-2 microglia (LPS conditioned media) to neuronal PC12 cells and improve cell viability. Polygalasaponin F can induce long-term potentiation in hippocampal dentate gyrus in anesthetized rats via NMDAR activation mediated by Ca(2+)/calmodulin-dependent kinase II, extracellular signal-regulated kinase and cAMP response element-binding protein signaling pathway. PS-F inhibits the secretions of neuroinflammatory cytokines by the regulation of the NF-kB-signaling pathway.
Bioactivity	Polygalasaponin F protects PC12 cells against rotenone-induced apoptosis via ameliorating the mitochondrial dysfunction. Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-alpha and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases.Polygalasaponin F can significantly inhibit the cytotoxicity of conditioned medium prepared by LPS-stimulated BV-2 microglia (LPS conditioned media) to neuronal PC12 cells and improve cell viability. Polygalasaponin F can induce long-term potentiation in hippocampal dentate gyrus in anesthetized rats via NMDAR activation mediated by Ca(2+)/calmodulin-dependent kinase II, extracellular signal-regulated kinase and cAMP response element-binding protein signaling pathway. PS-F inhibits the secretions of neuroinflammatory cytokines by the regulation of NF-kB-signaling pathway
Pathways	NF-Κb\|\|\|Immunology/Inflammation\|\|\|PI3K/Akt/mTOR signaling\|\|\|Cytoskeletal Signaling
Receptor	NF-kappaB

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