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Polyphyllin I

Polyphyllin I

Item no.	TMO-T3895-10mg
Manufacturer	TargetMol
CASRN	50773-41-6
Amount	10 mg
Quantity options	100 mg 10 mg 1 mg 200 mg 25 mg 500 mg 50 mg 5 mg
Category	Oncology Reagents & Chemicals Molecules By Organ Colorectal Cancer
Type	Molecules
Specific against	other
Citations	1. Wu L,et al. Polyphyllin D induces apoptosis in K562/A02 cells through G2/M phase arrest. Wu L1, Li Q, Liu Y.J Pharm Pharmacol. 2014 May;66(5):713-21.
Smiles	[H][C@]12C[C@@]3([H])[C@]4([H])CC=C5C[C@H](CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@@]1(CC[C@@H](C)CO1)O2)O[C@]1([H])O[C@H](CO)[C@@H](O[C@]2([H])O[C@@H](CO)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@]1([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Targets	mTOR\|\|\|Autophagy\|\|\|Apoptosis\|\|\|PDK\|\|\|JNK\|\|\|Akt
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	855.02
Description	Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D has an anti-angiogenic effect. Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis. Polyphyllin D has strong anticancer activity, can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction.
Pathways	MAPK\|\|\|PI3K/Akt/mTOR signaling\|\|\|Apoptosis\|\|\|Cytoskeletal Signaling\|\|\|Autophagy

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