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Calycosin

Calycosin

Item no.	TMO-T3923-50mg
Manufacturer	TargetMol
CASRN	20575-57-9
Amount	50 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	0,98
Citations	1. Chen J., et al. Calycosin and genistein induce apoptosis by inactivation of HOTAIR/p-Akt signaling pathway in human breast cancer MCF-7 cells. Cell Physiol Biochem. 2015;35(2):722-8.
Smiles	COc1ccc(cc1O)-c1coc2cc(O)ccc2c1=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	3'-Hydroxyformononetin, Cyclosin
Shipping condition	Cool pack
Available
Manufacturer - Targets	Tyrosinase\|\|\|Apoptosis
Shipping Temperature	cool pack
Storage Conditions	-20°
Molecular Weight	284, 26
Target names or alias	3'-Hydroxyformononetin , Cyclosin
Description	Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer cell growth via ERβ-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways. Calycosin has antineoplastic effects against osteosarcoma through inducing apoptosis showing in vitro and in vivo investigations. Calycosin was shown to induce angiogenesis in human umbilical vein endothelial cell cultures (HUVEC) in vitro. Calycosin may be an effective skin-lightening agent that regulates the expression of melanogenic enzymes. Calycosin exhibited tyrosinase inhibitory activity with an IC(50) value of 38.4 microM.
Pathways	Proteases/Proteasome\|\|\|Apoptosis

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