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Fevipiprant

Fevipiprant

Item no.	TMO-T3965-10mM
Manufacturer	TargetMol
CASRN	872365-14-5
Amount	1 mL x 10 mM (in DMSO)
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 200 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Sykes DA, et al. Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy. Mol Pharmacol. 2016 May;89(5):593-605.
Smiles	Cc1c(CC(O)=O)c2cccnc2n1Cc1ccc(cc1C(F)(F)F)S(C)(=O)=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	QAW039,NVP-QAW039
Shipping Condition	Cool pack
Available
Manufacturer - Targets	GPCR\|\|\|Prostaglandin Receptor
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	426.41
Description	Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.
Pathways	Immunology/Inflammation\|\|\|Endocrinology/Hormones\|\|\|GPCR/G Protein
Bioactivity	Fevipiprant(QAW039) is a selective, potent, reversible competitive CRTh2 antagonist with an in vitro dissociation constant KD value of 1.1nM at the CRTh2 receptor and an IC50 value of 0.44 nM for inhibition of PGD2-induced eosinophil shape change in human whole blood.
Receptor	CRTh2

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 mL x 10 mM (in DMSO)

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