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SGC2085 HCl

SGC2085 HCl

Item no.	TMO-T4013-10mg
Manufacturer	TargetMol
CASRN	1821908-49-9
Amount	10 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 1 mg 200 mg 25 mg 2 mg 50 mg 5 mg
Category	Oncology Reagents & Chemicals Molecules By Organ Breast Cancer
Type	Molecules
Specific against	other
Citations	1. Renato., et al. Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening . J Med Chem. 2016 Jul 28;59(14):6838-47.
Smiles	C(=O)([C@H](C)N)NCc1cc(c(cc1)Oc1cc(cc(c1)C)C)C.Cl
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Histone Methyltransferase inhibitor
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Histone Methyltransferase
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	348.87
Description	SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. CARM1 is an important positive modulator of Wnt/β-catenin transcription and neoplastic transformation in colorectal cancer as well as a critical factor in estrogen-stimulated breast cancer growth, and its depletion results in decreased proliferation of myeloid leukemia cells in vivo.
Pathways	Chromatin/Epigenetic

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mg

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