Comparison

Relebactam European Partner

Item no. TMO-T4017-2mg
Manufacturer TargetMol
CASRN 1174018-99-5
Amount 2 mg
Quantity options 100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 1 mg 25 mg 2 mg 50 mg 5 mg
Category
Type Molecules
Specific against other
Citations 1.Lapuebla A, et al. Activity of Imipenem with Relebactam against Gram-Negative Pathogens from New York City. Antimicrob Agents Chemother. 2015 Aug;59(8):5029-31.
Smiles OS(=O)(=O)ON1[C@H]2CN([C@@H](CC2)C(=O)NC2CCNCC2)C1=O
ECLASS 10.1 32169090
ECLASS 11.0 32169090
UNSPSC 12000000
Alias MK-7655
Shipping Condition Cool pack
Available
Manufacturer - Targets
Antibacterial
Shipping Temperature
Cool pack
Storage Conditions
-20
Molecular Weight
348.38
Description
Relebactam (MK-7655) is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases.
Pathways
Microbiology/Virology
Bioactivity
Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of beta-lactamases, including class A (extended-spectrum beta-lactamases [ESBLs] and KPC) and class C (AmpC) enzymes. Target: beta-lactamase Imipenem with Relebactam is active against Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp., including K. pneumoniae carbapenemase (KPC)-producing isolates. The combination of Imipenem with Relebactam demonstrated activity against KPC-producing Enterobacteriaceae and multidrug-resistant P. aeruginosa. The imipenem MIC50 and MIC90 values for the ESBL-producing isolates were 0.25 and 0.5 ug/ml, respectively; with the addition of Relebactam, the corresponding values were 0.25 and 0.25 ug/ml. Five isolates harbored blaKPC. For these 5 isolates, the imipenem MICs ranged from 0.5 to >32 ug/ml. With the addition of Relebactam, the MICs decreased to 0.12 to 0.5 ug/ml.1 Relebactam inhibits most class A and class C beta-lactamases, with selected inhibition of class D enzymes by avibactam. beta-Lactamase inhibitors (BLIs) have played an important role in combatting beta-lactam resistance in Gram-negative bacteria, but their effectiveness has diminished with the evolution of diverse and deleterious varieties of beta-lactamases.2
Receptor
diazabicyclooctane

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 2 mg
Available: In stock
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