AG-494

Item no.	TMO-T4205-10mM
Manufacturer	TargetMol
CASRN	133550-35-3
Amount	1 mL x 10 mM (in DMSO)
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 200 mg 25 mg 2 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Signaling Reagents & Chemicals Molecules By Organ Bladder Cancer
Type	Molecules
Specific against	other
Citations	1. Gazit, A. et al. Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors. Journal of Medicinal Chemistry 32(10), 2344-2352 (1989).
Smiles	Oc1ccc(\C=C(/C#N)C(=O)Nc2ccccc2)cc1O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Tyrphostin B48,AG 494,Tyrphostin AG-494
Shipping Condition	Cool pack
Available
Manufacturer - Targets	EGFR\|\|\|CDK
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	280.28
Description	AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.
Pathways	Angiogenesis\|\|\|Cell Cycle/Checkpoint\|\|\|Tyrosine Kinase/Adaptors\|\|\|JAK/STAT signaling
Bioactivity	Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative, compounds that act as PTK blockers. PTK inhibitors that preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation.1 AG-494 is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 1 uM in HT-22 cells.
Receptor	EGFR

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 mL x 10 mM (in DMSO)

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