E6446

Item no.	TMO-T4206-10mg
Manufacturer	TargetMol
CASRN	1219925-73-1
Amount	10 mg
Quantity options	100 mg 10 mg 1 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1: Dias AA,et al. DNA Sensing via TLR-9 Constitutes a Major Innate Immunity Pathway Activated during Erythema Nodosum Leprosum. J Immunol. 2016 Sep 1;197(5):1905-13.
Smiles	O(CCCN1CCCC1)C=2C=C3C(N=C(O3)C4=CC=C(OCCCN5CCCC5)C=C4)=CC2
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	TLR inhibitor
Shipping Condition	Cool pack
Available
Manufacturer - Targets	TLR
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	449.59
Description	E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. When administered to mice, this compound suppress responses to challenge doses of cytidine-phosphate-guanidine (CpG)-containing DNA, which stimulates TLR9.
Pathways	Immunology/Inflammation

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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