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I-CBP112 hydrochloride

I-CBP112 hydrochloride

Item no.	TMO-T4247-1mg
Manufacturer	TargetMol
CASRN	2147701-33-3
Amount	1 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 25 mg 2 mg 50 mg 5 mg
Category	Oncology Reagents & Chemicals Molecules By Organ Heart & Blood Cancer
Type	Molecules
Specific against	other
Citations	1. Zucconi BE, et al. Modulation of p300/CBP Acetylation of Nucleosomes by Bromodomain LigandI-CBP112. Biochemistry. 2016 Jul 12;55(27):3727-34.
Smiles	O(C[C@@H]1CN(C)CCC1)C2=C3C(=CC(=C2)C4=CC(OC)=C(OC)C=C4)CN(C(CC)=O)CCO3.Cl
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Epigenetic Reader Domain inhibitor
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Epigenetic Reader Domain
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	505.05
Description	I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 targets the CBP/p300 bromodomains. I-CBP112 significantly reduced the leukemia-initiating potential of MLL-AF9(+) acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. Interestingly, I-CBP112 increased the cytotoxic activity of BET bromodomain inhibitor JQ1 as well as doxorubicin.
Pathways	Chromatin/Epigenetic

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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