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RO1138452

RO1138452

Item no.	TMO-T4436-10mg
Manufacturer	TargetMol
CASRN	221529-58-4
Amount	10 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	0,9573
Citations	1.Clark R D, Jahangir A, Severance D, et al. Discovery and SAR development of 2-(phenylamino) imidazolines as postacyclin receptor antagonists[J]. Bioorganic & medicinal chemistry letters, 2004, 14(4): 1053-1056.
Smiles	CC(C)Oc1ccc(Cc2ccc(NC3=NCCN3)cc2)cc1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	CAY10441
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Prostaglandin Receptor
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	309.41
Description	RO1138452 (CAY10441) is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3). It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Likewise, it inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of about 1.5 nM. At levels between 2-20 mg/kg in rats, CAY10441 shows significant analgesic activity in standard antinociceptive assays [1].
Pathways	GPCR/G Protein\|\|\|Immunology/Inflammation

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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