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Ro5-3335

Ro5-3335

Item no.	TMO-T4687-50mg
Manufacturer	TargetMol
CASRN	30195-30-3
Amount	50 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 1 mg 200 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	0,98
Citations	1.Cunningham L, et al.Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFbeta interaction.Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14592-7.
Smiles	Clc1ccc2NC(=O)CN=C(c3ccc[nH]3)c2c1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	CBFβ-Runx1 inhibitor II,Ro 5-3335
Shipping Condition	Cool pack
Available
Manufacturer - Targets	DNA/RNA Synthesis
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	259.69
Description	Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Ro5-3335 represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Ro5-3335 also reduces the leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. It also is a Tat antagonist and inhibits HIV-1 replication in vitro.
Pathways	DNA Damage/DNA Repair\|\|\|Cell Cycle/Checkpoint

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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