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Selumetinib

Selumetinib

Item no.	TMO-T6218-1000mg
Manufacturer	TargetMol
CASRN	606143-52-6
Amount	1000 mg
Quantity options	1000 mg 100 mg 1 mL x 10 mM (in DMSO) 1 g 1 mL 200 mg 20 mg 25 mg 500 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Signaling Reagents & Chemicals Molecules By Organ Bladder Cancer
Type	Molecules
Specific against	other
Citations	1. Huynh H, et al, Mol Y Therapy, 2007, 6 (1), 138-146
Smiles	CN1C=NC2=C(F)C(NC3=CC=C(Br)C=C3Cl)=C(C=C12)C(=O)NOCCO
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	ARRY-142886,AZD6244
Shipping Condition	Cool pack
Available
Manufacturer - Targets	MEK\|\|\|ERK\|\|\|Apoptosis
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	457.68
Description	Selumetinib (AZD6244) is a MEK1/2 inhibitor that inhibits MEK1 (IC50=14 nM) with potent selectivity and is non-ATP-competitive. Selumetinib has antitumor activity and is used for the treatment of neurofibromatosis type 1 (NF1).
Pathways	Apoptosis\|\|\|MAPK
Bioactivity	Selumetinib (AZD6244) is a potent, highly selective MEK1 inhibitor with IC50 of 14 nM, also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38alpha, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. Phase 3.
Receptor	MEK1

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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