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Ipatasertib

Ipatasertib

Item no.	TMO-T6252-1mg
Manufacturer	TargetMol
CASRN	1001264-89-6
Amount	1 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 g 1 mg 1 mL 200 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	0,9828
Citations	1. Lin K. Cancer Res, 2011, 71(8 Supplement), abstract DDT02-01.
Smiles	C[C@H]1C2=C(N=CN=C2[C@H](O)C1)N3CCN(C([C@H](CNC(C)C)C4=CC=C(Cl)C=C4)=O)CC3
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	GDC-0068,RG7440
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Akt
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	458
Description	Ipatasertib (GDC-0068) is a selective, ATP-competitive pan-Akt inhibitor that inhibits Akt1 (IC50:5 nM), Akt2 (IC50:18 nM), and Akt3 (IC50:8 nM). Ipatasertib (GDC-0068) can lead to p53-independent PUMA activation by inhibiting Akt, thereby activating FoxO3a and NF-κB simultaneously, directly binding to the PUMA promoter, upregulating PUMA transcription and Bax-mediated intrinsic mitochondrial apoptosis.
Pathways	PI3K/Akt/mTOR signaling\|\|\|Cytoskeletal Signaling
Bioactivity	Ipatasertib (GDC-0068), a highly specific pan-Akt inhibitor, targets Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, respectively.
Receptor	Akt1; Akt2; Akt3

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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