R547

Item no.	TMO-T6312-25mg
Manufacturer	TargetMol
CASRN	741713-40-6
Amount	25 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 1 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	0,98
Smiles	COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(CC2)S(C)(=O)=O)nc1N
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Ro 4584820
Similar products	741713-40-6
Shipping Condition	Cool pack
Available
Manufacturer - Targets	GSK-3\|\|\|Apoptosis\|\|\|PKA\|\|\|CDK
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	441.45
Description	R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1.
Pathways	Tyrosine Kinase/Adaptors\|\|\|PI3K/Akt/mTOR signaling\|\|\|Stem Cells\|\|\|Cell Cycle/Checkpoint\|\|\|Apoptosis

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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