Butein

Item no.	TMO-T6427-2mg
Manufacturer	TargetMol
CASRN	487-52-5
Amount	2 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 25 mg 2 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Neural Transcription Factors Neural Signaling Reagents & Chemicals Molecules By Organ Bladder Cancer
Type	Molecules
Specific against	other
Citations	1. Yang EB, et al. Biochem Biophys Res Commun, 1998, 17, 245(2), 435-438.
Smiles	Oc1ccc(C(=O)\C=C\c2ccc(O)c(O)c2)c(O)c1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	2',3,4,4'-tetrahydroxy Chalcone
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Autophagy\|\|\|PDE\|\|\|EGFR\|\|\|Apoptosis
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	272.25
Description	Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator. It sensitizes HeLa cells to Cisplatin by targeting FoxO3a via the AKT and ERK/p38 MAPK pathways.
Pathways	Metabolism\|\|\|Tyrosine Kinase/Adaptors\|\|\|Autophagy\|\|\|Angiogenesis\|\|\|Apoptosis\|\|\|JAK/STAT signaling

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