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Golvatinib

Golvatinib

Item no.	TMO-T6517-10mg
Manufacturer	TargetMol
CASRN	928037-13-2
Amount	10 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 25 mg 2 mg 50 mg 5 mg
Category	Oncology Reagents & Chemicals Molecules By Organ Colorectal Cancer
Type	Molecules
Specific against	other
Citations	1. Nakagawa T et al. Cancer Sci, 2010, 101(1), 210-215.
Smiles	CN1CCN(CC1)C1CCN(CC1)C(=O)Nc1cc(Oc2ccc(NC(=O)C3(CC3)C(=O)Nc3ccc(F)cc3)c(F)c2)ccn1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	E-7050
Shipping Condition	Cool pack
Available
Manufacturer - Targets	VEGFR\|\|\|c-Met/HGFR
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	633.69
Description	Golvatinib (E-7050) is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity. c-Met/VEGFR kinase inhibitor E7050 binds to and inhibits the activities of both c-Met and VEGFR-2, which may inhibit tumor cell growth and survival of tumor cells that overexpress these receptor tyrosine kinases. c-Met and VEGFR-2 are upregulated in a variety of tumor cell types and play important roles in tumor cell growth, migration and angiogenesis.
Pathways	Angiogenesis\|\|\|Tyrosine Kinase/Adaptors

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