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Olmutinib

Olmutinib

Item no.	TMO-T6918-5mg
Manufacturer	TargetMol
CASRN	1353550-13-6
Amount	5 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 200 mg 25 mg 2 mg 50 mg 5 mg 100 mg 1 mL x 10 mM (in DMSO) 10 mg 200 mg 25 mg 2 mg 50 mg
Category	Oncology Neuroscience Neural Signaling Reagents & Chemicals Molecules By Organ Bladder Cancer
Type	Molecules
Specific against	other
Citations	1. Wang S, et al. J Hematol Oncol. 2016, 9: 34.
Smiles	CN1CCN(CC1)c1ccc(Nc2nc(Oc3cccc(NC(=O)C=C)c3)c3sccc3n2)cc1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	HM61713,BI 1482694,BI 1482694,HM61713
Shipping Condition	Cool pack
Available
Manufacturer - Targets	BTK\|\|\|EGFR
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	486.59
Description	Olmutinib (HM61713, BI 1482694) is an orally available small molecule, a mutant-selective inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic activity. Olmutinib binds to and inhibits mutant forms of EGFR, thereby leading to cell death of EGFR-expressing tumor cells. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced as compared to non-selective EGFR inhibitors which also inhibit the EGFR wild-type form.
Pathways	JAK/STAT signaling\|\|\|Angiogenesis\|\|\|Tyrosine Kinase/Adaptors

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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