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ON123300

ON123300

Item no.	TMO-T6920-25mg
Manufacturer	TargetMol
CASRN	1357470-29-1
Amount	25 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Oncology Neuroscience Molecular Targets for Neuroscience Reagents & Chemicals Molecules By Organ Lymphatic System Cancer
Type	Molecules
Specific against	other
Citations	1. Perumal D., Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Inhibitor ON123300 Exerts Potent Anticancer Activity against Multiple Myeloma. Cancer Res. 2016 Mar 1;76(5):1225-36.
Smiles	CN1CCN(CC1)c1ccc(Nc2ncc3cc(C#N)c(=O)n(C4CCCC4)c3n2)cc1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	CDK inhibitor
Shipping Condition	Cool pack
Available
Manufacturer - Targets	PDGFR\|\|\|c-RET\|\|\|AMPK\|\|\|Src\|\|\|JAK\|\|\|FGFR\|\|\|CDK
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	429.52
Description	ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).
Pathways	Tyrosine Kinase/Adaptors\|\|\|Angiogenesis\|\|\|Cell Cycle/Checkpoint\|\|\|Stem Cells\|\|\|Chromatin/Epigenetic\|\|\|Apoptosis\|\|\|JAK/STAT signaling\|\|\|PI3K/Akt/mTOR signaling

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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