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Pamapimod

Pamapimod

Item no.	TMO-T6927-2mg
Manufacturer	TargetMol
CASRN	449811-01-2
Amount	2 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Hill RJ, et al. J Pharmacol Exp Ther. 2008, 327(3):610-9.
Smiles	Cn1c2nc(NC(CCO)CCO)ncc2cc(Oc2ccc(F)cc2F)c1=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	R1503,Ro4402257
Shipping Condition	Cool pack
Available
Manufacturer - Targets	p38 MAPK\|\|\|Autophagy
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	406.38
Description	Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectively with no activity against p38delta or p38 gamma isoforms.
Pathways	Autophagy\|\|\|MAPK
Bioactivity	Pamapimod (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38alpha and p38beta enzymatic activity with IC50 values of 0.014+/-0.002 and 0.48+/- 0.04 microM, respectively with no activity against p38delta or p38gamma isoforms.
Receptor	p38alpha; p38beta

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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